AACR 2023 - Lunaphore Technologies

Novel data.
New products.
Meet the future at #AACR23.

What will the next decade of spatial biology look like? Connect with Lunaphore at #AACR23 to experience the new paradigm shift we are bringing to the spatial biology space.

BOOTH #1870: PRODUCT DEMO & RAW DATASET

Make sure to stop by the Lunaphore booth to receive a 2-minute walkthrough of the COMET™ platform and freely browse raw multiplex images on several tissue types. Book a meeting with our team to learn how top-notch laboratories, biopharma and CROs are leveraging COMET™: the only fully automated, high-throughput, hyperplex platform that works with off-the-shelf, label-free primary antibodies.

📅 April 16 – 19
📍 Booth #1870

BOOK A MEETING WITH LUNAPHORE →
(Clicking on the link you will be able to select your preferred meeting time)

SCIENTIFIC PRESENTATION – Spotlight Theater D

Book your agenda to know more about how the team at Northwestern University exploited the COMET™ platform to build a universal and comprehensive panel profiling the central nervous system microenvironment. Check the full talk abstract below.

Profiling the Central Nervous System Microenvironment Using Hyperplex Immunofluorescence
Speaker:

Hinda J. Najem, M.D., M.Sc., Northwestern University

📋 Session ESP05D
📅 April 17 – 3:00 PM
📍 AACR Conference Hall – Spotlight Theater D
📲 Bookmark this session on the conference website/app →

DINNER SYMPOSIUM – “The next decade of spatial biology”

Lunaphore is happy to welcome you for some science, exciting news, and drinks at its exclusive dinner symposium affiliated with AACR 2023. Join us to discover how world-class experts are leveraging COMET™ to answer novel biological questions and exploit the open roundtable to learn more about the challenges and opportunities that spatial biology will face in the next decade. Registration is free, but seats are limited. Check the full event agenda below.

The next decade of spatial biology
Guest speakers:

Dr. Denis Schapiro – Group leader, Heidelberg University Hospital
Dr. Jérôme Galon – Director of Research, INSERM
Dr. Travis Hollmann – Scientific Director, Translational Medicine, Bristol Myers Squibb
Dr. Michael Surace – Director, AstraZeneca

Moderator:

Dr. Joanna Kowal – Senior Scientific Affairs Manager, Lunaphore

📅 April 17 – 6:30 PM
📍 Rosen Centre Hotel – Room Signature 1 (Block adjacent to the conference center)

RESERVE YOUR SEAT NOW →
(Clicking on the link you will download an event that can be added to your calendar)

POSTER PRESENTATIONS – Scientific programme

The novel data brought at AACR 2023 will outline COMET™’s industry-leading capabilities and highlight its wide range of research applications and broad clinical potential.

POSTER #5642
Validation of a novel multiplex immuno-fluorescence panel for the spatial analysis of the tumor microenvironment
📋 Bookmark or read the abstract in the scientific programme →

Poster #4620
Automated multiplex immunofluorescence workflow to interrogate the cellular composition of the tumor microenvironment
📋 Bookmark or read the abstract in the scientific programme →

Poster #6773
Spatial dynamics of cytotoxic T Lymphocyte exhaustion in reactive and tumoral tissue
Research conducted by KU Leuven, Belgium
📋 Bookmark or read the abstract in the scientific programme →

Poster #4619
Spatial analysis of the immunosuppressive tumor microenvironment in brain cancer applying a novel multiplex immunofluorescence panel
Research conducted in collaboration with the Institute of Neurology (Edinger Institute), University Hospital, Goethe University, Germany
📋 Bookmark or read the abstract in the scientific programme →

Poster #2254
Immunotopography characterization after neoadjuvant therapy in the pancreatic cancer microenvironment
Research conducted in collaboration with the Department of Surgery, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Germany
📋 Bookmark or read the abstract in the scientific programme →

Poster #4616
Automated multiplex immunofluorescence enables single cell analysis of tumor stroma
Research conducted in collaboration with Abcam, United Kingdom
📋 Bookmark or read the abstract in the scientific programme →

Poster #4336
Automation of proximity ligation immunoassay for PD-L1/PD-1 detection in the tumor microenvironment using microfluidic-based system
Research conducted in collaboration with Navinci Diagnostics, Sweden
📋 Bookmark or read the abstract in the scientific programme →

Lunaphore solutions will be featured in the following poster presentations.:

POSTER #5642
Validation of a novel multiplex immuno-fluorescence panel for the spatial analysis of the tumor microenvironment

📋 Session PO.CL01.12 – Spatial Proteomics and Transcriptomics 1
📅 April 18 – 1:30 PM – 5:00 PM
📍 Section 43
📥 DOWNLOAD THE POSTER

Poster #4620
Automated multiplex immunofluorescence workflow to interrogate the cellular composition of the tumor microenvironment

📋 Session PO.TB11.09 – Evaluating Tumor Progression via 3D and Spatial Approaches
📅 April 18 – 1:30 PM – 5:00 PM
📍 Section 4
📥 DOWNLOAD THE POSTER

Poster #6773
Spatial dynamics of cytotoxic T Lymphocyte exhaustion in reactive and tumoral tissue
Research conducted by KU Leuven, Belgium

📋 Session PO.CL01.13 – Spatial Proteomics and Transcriptomics 2
📅 April 19 – 9:00 AM – 12:30 PM
📍 Section 43
📲 BOOKMARK ON THE CONFERENCE WEBSITE/APP

Poster #4619
Spatial analysis of the immunosuppressive tumor microenvironment in brain cancer applying a novel multiplex immunofluorescence panel
Research conducted in collaboration with the Institute of Neurology (Edinger Institute), University Hospital, Goethe University, Germany

📋 Session PO.TB11.09 – Evaluating Tumor Progression via 3D and Spatial Approaches
📅 April 18 – 1:30 PM – 5:00 PM
📍 Section 4
📲 BOOKMARK ON THE CONFERENCE WEBSITE/APP

Poster #2254
Immunotopography characterization after neoadjuvant therapy in the pancreatic cancer microenvironment
Research conducted in collaboration with the Department of Surgery, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Germany

📋 Session PO.CL07.09 – Immune Response to Therapies
📅 April 17 – 9:00 AM – 12:30 PM
📍 Section 43
📲 BOOKMARK ON THE CONFERENCE WEBSITE/APP

Poster #4616
Automated multiplex immunofluorescence enables single cell analysis of tumor stroma
Research conducted in collaboration with Abcam, United Kingdom

📋 Session PO.TB11.09 – Evaluating Tumor Progression via 3D and Spatial Approaches
📅 April 18 – 1:30 PM – 5:00 PM
📍 Section 4
📥 DOWNLOAD THE POSTER

Poster #4336
Automation of proximity ligation immunoassay for PD-L1/PD-1 detection in the tumor microenvironment using microfluidic-based system
Research conducted in collaboration with Navinci Diagnostics, Sweden

📋 Session PO.CL01.04 – Biomarkers of Therapeutic Benefit 4
📅 April 18 – 9:00 AM – 12:30 PM
📍 Section 37
📥 DOWNLOAD THE POSTER

Visit booth #1870 to check our latest product releases.

Lunaphore’s multiplex immunofluorescence (mIF) solution portfolio now includes the latest version of the hyperplex, high-throughput, fully automated COMET™ instrument, providing unmatched scalability and reproducibility without the need to conjugate primary antibodies. The new SPYRE™ Antibody Panel kits, Secondary Antibodies, and an online Panel Builder have been added to the existing offering to help kick-start assay development and enable users with verified biomarkers on COMET™.

The product suite is further complemented by HORIZON™, an image analysis software designed and tailored for COMET™ hyperplex images. The software is developed by biologists for biologists to support them in answering fundamental questions about cell profiling and tissue mapping. With Lunaphore’s universal portfolio of precision automation solutions, customers can leverage their existing antibody libraries and decades of know-how on Lunaphore’s platform to scale assays into endless multiplexing possibilities.

For exclusive details make sure to attend our AACR Dinner Symposium.

For info, meeting requests, or support please contact [email protected].

Scientific presentation

Check the agenda →

April 17

3:00 PM

Conference Hall - Spotlight Theater D

Hyperplex immunofluorescence enables the interrogation of tissue composition at single-cell level, including quantitative information about cell distribution, neighborhoods, and interactions. It can also complement existing omics techniques to increase observations and generate new hypotheses. Our study analysis includes diverse central nervous system (CNS) tumor samples together with the rarely profiled adjacent brain, and conditions such as epilepsy and IgG4 disease. Exploiting the flexibility of panels built with label-free antibodies, the automated COMET™ platform and a rapid optimization workflow, we developed a comprehensive and universal CNS profiling panel that can benefit the field of neuroscience as a tool to unravel CNS microenvironment.

Speaker

Hinda Najem, M.D., Ph.D.

Postdoctoral Research Fellow

Northwestern University

Dr. Najem is currently a postdoctoral fellow at Dr. Amy Heimberger’s Lab at Northwestern University. She obtained her medical doctor degree in July 2020 from St. Joseph University, Beirut, Lebanon. While working on her clinical medical practice, she worked for almost 3 years in pre-clinical research, when she obtained her master’s degree in Biological and Medical Sciences in December 2018 at the Physiology and Physiopathology Laboratory, St. Joseph University, Beirut, Lebanon. She joined Dr. Heimberger’s lab in November 2020 at MD Anderson Cancer Center and transferred to Northwestern University in May 2021. She is working on brain tumors’ immune profiling, immune modulation, molecular pathways responsible for immunosuppression in the tumor microenvironment, and has published 15 manuscripts in that time. She is also working on pre-clinical animal models of gliomas and on humanized mouse models, studying the effect of STING agonists and other immune therapeutic strategies.

Dinner Symposium

Check the agenda →

April 17

6:30 PM

Rosen Centre Hotel - Room Signature 1

6:30 PM
Doors Open – Welcome drinks & networking

7:00 PM
Dr. Ata Tuna Ciftlik
Welcome remarks

7:10 PM
Dr. Jerome Galon
A “space” journey: from immunoscore to spatial immunofluorescence

7:30 PM
Dr. Denis Schapiro
“Google Maps” for tissue biology – Mapping tissues with spatial omics technologies

7:50 PM
Dr. Travis Hollmann, Dr. Jerome Galon, Dr. Denis Schapiro, Dr. Micheal Surace
ROUNDTABLE – The future is now: the next decade of spatial biology

8:15 PM
Cocktails & networking

Speakers

Denis Schapiro, Ph.D.

Group Leader, Institute for Computational Biomedicine and Institute of Pathology

University Hospital Heidelberg

Dr. Denis Schapiro is a Group Leader at the Heidelberg University Hospital focusing on spatial omics technologies and analysis. Before moving to Heidelberg, he was an Independent Fellow at the Laboratory of Systems Pharmacology at Harvard Medical School and the Klarman Cell Observatory at the Broad Institute where he was a Damon Runyon Quantitative Biology Fellow mentored by Prof. Peter Sorger and Prof. Aviv Regev. Previously, he was supported by the SNFS Mobility Fellowship. Denis obtained his PhD from the University of Zurich and ETH Zurich in the laboratory of Prof. Bernd Bodenmiller. Denis is the lead developer of the histology topography cytometry analysis toolbox (histoCAT) and the multiple-choice microscopy pipeline (MCMICRO).

Jérôme Galon, Ph.D.

Head of the Laboratory of Integrative Cancer Immunology

Centre de Recherche des Cordeliers

Travis Hollmann, Ph.D.

Scientific Director, Translational Medicine

Bristol Myers Squibb

Dinner Symposium Registration

The next decade of spatial biology