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Poster

AACR 2023 – Spatial analysis of the immunosuppressive tumor microenvironment in brain cancer applying a novel multiplex immunofluorescence panel

Research conducted in collaboration with University of Frankfurt, Germany

Poster

Immune Spatial Differences Between Short and Long-term Surviving Glioblastoma Patients

Webinar

Frontline Genomics: “Spatial Biology In Cancer And Immuno-oncology”

Replay Webinar

Poster

AACR 2023 – Automation of Proximity Ligation Immunoassay for interaction between PD-L1 and PD-1 detection in the tumor microenvironment using microfluidic-based systems

Research conducted in collaboration with Navinci Diagnostics, Sweden

Poster

AACR 2023 – Automated multiplex immunofluorescence enables single cell analysis of tumor stroma

Research conducted in collaboration with Abcam, United Kingdom

Poster

AACR 2023 – Automated multiplex immunofluorescence workflow to interrogate the cellular composition of the tumor microenvironment

Vytautas Navikas, Quentin Juppet, Samuel Aubert, Benjamin Pelz, Joanna Kowal, Diego G Dupouy, Lunaphore Technologies S.A., Tolochenaz, Switzerland

Poster

AACR 2023 – Validation of a novel multiplex immuno-fluorescence panel for the spatial analysis of the tumor microenvironment

François Rivest, Victor de Gautard, Vytautas Navikas, Dakota Suchyta, Bastian Nicolai, Saška Brajković, Lunaphore Technologies S.A., Tolochenaz, Switzerland

Product Brochure

HORIZON™

Product Brochure

SPYRE™ Antibody Panels

Publication

Tissue-Resident Memory T Cells in Pancreatic Ductal Adenocarcinoma Coexpress PD-1 and TIGIT and Functional Inhibition Is Reversible by Dual Antibody Blockade

Pearce H, et al. 2023

Webinar

Mapping immune cell infiltrates in the tumor microenvironment using hyperplex immunofluorescence

Replay Webinar

Publication

Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

Pugh M, et al. 2022

Poster

Mapping the heterogeneous colorectal tumor microenvironment with multiplexed imaging and machine learning

Poster

Characterization of tumor budding and the tumor microenvironment in colorectal cancer using hyperplex immunofluorescence

Poster

Development of a multiplex test for predicting response to combined immunotherapies in patients with metastatic melanoma

Poster

Mapping the tumor microenvironment with sequential immunofluorescence, an automated image analysis pipeline, and spatial metrics

Poster

Signal amplification strategies for in situ detection of low-expressed markers in multiplex immunofluorescence

Poster

Mapping the tissue composition with hyperplex immunofluorescence on delicate samples

Poster

Fully automated spatial multi-omics to map the tumor microenvironment with single-cell resolution

Publication

A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome

Nayar S, et al. 2022

Publication

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 Expression as a Driver of Gastric Differentiation and Indolent Biological Potential

Sans M, et al. 2022

Publication

The association between the tumor immune microenvironments and clinical outcome in low-grade, early-stage endometrial cancer patients

Lopez-Janeiro A, et al. 2022

Technical Note

COMET™ streamlines hyperplex immunofluorescence at single-cell resolution

Infographic

Using spatial biology to advance biomarker discovery and personalized medicine

Publication

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke

Spitzer D, et al. Acta Neuropathologica (2022) 144:305–337

Infographic

Spatial Biology Infographic

Technical Note

A core 10-plex panel to accelerate immuno-oncology research

Poster

Integrating hyperplex immunofluorescence, automated image acquisition, and analysis to map the cellular architecture of the tumor microenvironment.

Poster

Mapping the spatial heterogeneity of the tumor microenvironment by hyperplex immunofluorescence with COMET™

Publication

Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

Fan R, et al. 2022

Poster

ABRF 2022 – Mapping the cellular architecture of the tumor microenvironment by integrating hyper¬plex immunofluorescence and automated image analysis

Poster

AACR 2022 – Mapping the cellular architecture of the tumor microenvironment by integrating hyper¬plex immunofluorescence and automated image analysis

Technical Note

Sequential immunofluorescence on LabSat®

Technical Note

Elution efficiency and epitope stability with COMET™

Technical Note

COMET™ How to reduce and remove autofluorescence

Technical Note

Multiplex assays easily optimized on LabSat® and directly transferred to high-throughput instruments

Product Brochure

LabSat® Technical Specifications

Technical Note

COMET™ Assay Validation

Technical Note

Assay development of immuno-oncology panels with COMET™

Product Brochure

COMET™ The only high-throughput, hyperplex platform

Product Brochure

LabSat® Your introduction to spatial biology

Technical Note

From a tissue to another one: easy adaptation of a core immuno-oncology panel

Technical Note

10-plex immuno-oncology panel on COMET™

Technical Note

Automation of RNAscope™ assays in immuno-oncology research on LabSat®

Technical Note

Fast biomarker optimization on LabSat®

Technical Note

Fast and automated TSA-based multiplexed immunofluorescence on LabSat®

Publication

The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

Niesel K, et al. EMBO Mol Med. 2021;13(e13412).

Publication

Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling

Lopez-Janeiro A, et al. Cancers. 2021;13(4): 794.

Publication

Microfluidic-based immunohistochemistry combined with next-generation sequencing on diagnostic tissue sections for detection of tumoral BRAF V600E mutation

Leblond L-A, et al. American Journal of Clinical Pathology. 2019;152(1): 59-73.

Publication

Ultra-fast and automated immunohistofluorescent multistaining using a microfluidic tissue processor

Cappi G, et al. Scientific Reports. 2019;9(4489).

Publication

Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections

Migliozzi D, et al. Microsystems & Nanoengineering. 2019;5(59).

Publication

Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study

Aimi F, et al. Virchows Arch. 2019;475: 313–323.

Publication

A microfluidic platform towards automated multiplexed in situ sequencing

Maïno N, et al. Scientific Reports. 2019;9(3542).

Publication

Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma

Brajkovic S, et al. Diagnostic Pathology. 2018;13(79).

Publication

Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment in breast cancer

Nguyen HT, et al. Laboratory Investigation. 2017;97: 93-103.

Publication

Microfluidics for rapid cytokeratin immunohistochemical staining in frozen sections

Brajkovic S, et al. Laboratory Investigation. 2017;97: 983–991.

Publication

Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer

Dupouy DG, et al. Scientific Reports. 2016;6(20277).

Publication

Microfluidic processor allows rapid HER2 immunohistochemistry of breast carcinomas and significantly reduces ambiguous (2+) read-outs

Ciftlik AT, et al. Proceedings of the National Academy of Sciences USA (PNAS). 2013;110(14): 5363-5368.

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