SPYRE™
Antibody Panels & Panel Builder
Get inspired to build new assays with modular tools
Lunaphore’s SPYRE™ Antibody Panels target key immuno-oncology and immune markers, enabling the seamless transfer of immunofluorescence protocols into a COMET™ hyperplex assay to accelerate biomarker identification and validation. Designed for maximum flexibility and minimal effort, SPYRE™ panels consist of label-free primary antibodies that eliminate cumbersome conjugation steps and can be easily customized with any antibody from your own library. Addressing the complexity of the tumor microenvironment, including stromal compartments, the SPYRE™ portfolio offers a modular combination of Core Panels, Focus Panels, and tumor-specific antibodies. These are validated and preconfigured sets covering essential markers in immuno-oncology and tumor biology. Pre-tested antibodies, lot-to-lot consistency, and pre-developed protocols save time in validation and optimization, allowing researchers to focus directly on their biological questions. Furthermore, researchers can streamline panel design with Lunaphore’s Panel Builder, an intuitive online tool for creating ready-to-use experimental protocols in silico. The new Community Marker Library further expands flexibility, enabling users to share and import validated markers and protocols within the COMET™ community.
The SPYRE™ Antibody Panel advantages
Modular panel building
Build custom panels of your required plex level.
Combine panel modules and “add-on” antibodies easily with the Panel Builder to address your biological questions.
Ready-to-use protocols on COMET™
Obtain protocols designed for COMET™ from the Panel Builder and directly run them on the instrument.
Label-free antibodies
Leverage your existing antibody know-how and avoid complex, time-consuming upstream conjugations. Use clones with proven specificity.
Custom hyperplex protocols in a few clicks
Within the SPYRE Antibody Core Panel offering we provide four different kits tailored to specific tumor microenvironment investigations offering unmatched speed in assay development on COMET™. Complementary SPYRE™ Stroma Focus Panel and SPYRE™ Vessel Focus Panel expand coverage to key stromal and vascular markers, while tumor-specific antibodies provide a comprehensive view of the tumor biology.
Leverage Lunaphore’s extensive expertise with SPYRE™ Antibody Panels for human FFPE samples and access a broad library of widely used antibodies. Easily tailor your assay by adding new markers from your own collection to meet specific research needs using the intuitive Panel Builder online tool.
Tap to toggle on and off
Human FFPE Tonsil tissue
Staining with: SPYRE™ IO Core Panel + CK. Protocol time: 6h30. Image post-processing: Background subtracted and brightness adjusted.
Leverage our expertise and accelerate your panel development with Panel Builder
The online Panel Builder provides exclusive access to a growing library of 200+ successfully tested antibodies providing all relevant information. It creates ready-to-use protocol files for COMET™ based on your desired SPYRE™ Antibody Panel and add-on markers from our library. In addition, panels can be further expanded with any antibody of your choice. This solution enables you to save time and streamline successful spatial biology experiments.
SPYRE™ Immuno-Oncology Core Panel kit
The SPYRE™ Immuno-Oncology Core Panel kit enables identification of immune, stromal and functional cell statuses.
SPYRE™ Immune Core Panel kit
The SPYRE™ Immune Core Panel kit enables identification of immune cells.
SPYRE™ TIL Core Panel kit
The SPYRE™ TIL Core Panel kit enables characterization of TIL subtypes, their expression, cellular co-localization and neighbourhood patterns.
SPYRE™ T Cell Core Panel kit
The SPYRE™ T Cell Core Panel kit enables identification and characterization of T cells.
Breast cancer
Tregs detected at single-cell resolution with SPYRE™ Antibody Panel on COMET™.
Melanoma
Immunosuppressive phenotypes such as PD-L1+ tumor cells can be identified with SPYRE™ Antibody Panels.
Breast cancer
Activated and exhausted lymphocytes such as PD-1+ T cells can be identified with SPYRE™ Antibody Panels.
Human Melanoma
SPYRE™ Focus Panels These validates panels target critical biological domains across tumor, stromal, and vascular biology.
Human Breast Cancer
SPYRE™ Focus Panels These validates panels target critical biological domains across tumor, stromal, and vascular biology.