SPYRE™ Signal Amplification Kit

Make every marker count

While most protein markers can be detected with standard indirect immunofluorescence methods, markers with low signal levels sometimes remain difficult to visualize. The SPYRE™ Signal Amplification, fully integrated with the COMET™ platform, amplifies the signal for low-expressed or hard-to-detect markers. It offers high-sensitivity detection you need without compromising on accuracy.

The SPYRE™ Signal Amplification advantages

Sensitive

Enhanced detection of challenging or low-expressed markers tailored to COMET™.

Quantifiable

Detect faint signals while preserving quantification accuracy, ensuring reliable results.

Flexible

Amplify the signal of your target in any cycle of your seqIF™ panel using any off-the-shelf primary antibody of mouse or rabbit origin. The amplified signal can be eluted for consecutive rounds of detection.

Seamless integration with COMET™

Based on sequential immunofluorescence (seqIF™) technology, the sequential layered amplification (seqLA™) method enhances the detection of secondary antibodies bound to primary antibodies by utilizing linker molecules.

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