Discover spatial multiomics on COMET™
Fully-automated, same-section, spatial RNA and protein detection at subcellular resolution
Now compatible with fresh frozen tissue samples
COMET™ enables the simultaneous spatial detection of RNA and protein on the same tissue section using RNAscope™ HiPlex Pro and sequential immunofluorescence (seqIF™) with off-the-shelf, non-conjugated primary antibodies. Thanks to the highly specific and sensitive detection of both targets, COMET™ provides valuable scientific insights into biomarkers that can be spatially resolved at single-cell level. The streamlined, end-to-end workflow ensures assay reproducibility and saves time in assay development and execution.
True spatial multiomics
Same-section multiomics
Integrate and correlate spatial RNA and protein data at single-cell level.
Fully-automated workflow
From target probe hybridization and protein detection to imaging in the same run. Click start and walk away, with up to 4 slides per run.
Any target
Choose virtually any RNA and protein target. Full flexibility to meet your research needs.
Any tissue type
Offers broad tissue compatibility, supporting FFPE, fixed frozen, and now fresh frozen samples.
Protease-free, fully-automated multiomics workflow
A fully integrated system across target probe hybridization, staining, image acquisition and image pre-processing.
A universal solution from discovery to translational research
Replace non-specific or unavailable antibodies with RNA targets
Run experiments using FFPE, fixed and fresh frozen samples with subcellular resolution
Perform studies on:
- secreted molecules, e.g. cytokine and chemokine
- cross-validation and co-expression
- tumor microenvironment (TME), gene therapy and
infectious diseases - predictive biomarkers and signature validation
- any animal tissue (non-human, non-mice)
Section of whole mouse brain, Amyotrophic lateral sclerosis, FS tissue
Slc17a7 Chat Slc17a6 NeuN GFAP TSPO
Mouse brain, Hippocampus, Amyotrophic lateral sclerosis, FS tissue. Dot mask is generated with HORIZON™
Rbfox3 Prox1 NeuN GFAP
Mouse brain, FS tissue
Prox1 Cldn5 GFAP NeuN
Mouse brain, Cerebral Cortex, Amyotrophic lateral sclerosis, FS tissue. Dot mask is generated with HORIZON™
Slc17a7 Gad1 NefH CD31 TSPO
Mouse brain, Medulla, Amyotrophic lateral sclerosis, FS tissue. Dot mask is generated with HORIZON™
Chat Slc17a6 GFAP Iba1 αSMA
Mouse brain, Blood Brain Barrier, Amyotrophic lateral sclerosis, FS tissue. Dot mask is generated with HORIZON™
Tubb3 Pdgfrb Cldn5 F4/80 GFAP CD31 NeuN
Human breast cancer, FFPE tissue
UBC RPL28 RPL5 GAPDH CK DAPI
Human breast cancer, FFPE tissue
UBC RPL28 RPL5 GAPDH CK