September 1-3
London, UK
The Royal Society
Resolving Cancer Biology Through Same-Section Spatial Multiomics at Subcellular Resolution
Bio-Techne Spatial is a leader in applied spatial biology, empowering scientists and clinicians to push the boundaries of basic and translational research. Built on the gold-standard RNAscope™ technology, our comprehensive portfolio of reagents, instruments, and analysis software delivers targeted, scalable solutions for low- to high-plex RNA and protein detection, from single-target ISH to 100+ plex same-section spatial multiomics.
Meet with us at the Royal Society in London for the Cancer Grand Challenges Spatial Biology conference to explore how RNAscope™ and COMET™ assays are enabling researchers to answer fundamental questions in cancer research, from mapping rare transcripts in the tumor microenvironment to spatially resolving complex cellular and molecular mechanisms at subcellular resolution. Learn about RNAscope™ HiPlex for high-plex RNA detection and discover how pairing RNAscope™ HiPlex Pro with our seqIF™ spatial proteomics workflow on the COMET™ platform enables fully-automated, end-to-end spatial multiomics, integrating RNA and protein detection on a single tissue section, with the reproducibility needed to generate publication-quality data.
Stop by our booth to meet our team or book a 1:1 session with our scientists to discuss your research questions.
Scientific Activities
September 1
Presentation
Tuesday, September 1
5:30–5:40 PM
Main Hall
Resolving the spatial organization of the tumor microenvironment is central to understanding immune evasion, predicting response to immunotherapy, and stratifying patients. Meeting these goals requires technologies that can co-detect transcripts and proteins in intact tissue, at single-cell resolution, without exhausting limited clinical samples. Bio-Techne Spatial delivers an integrated solution built for this challenge.
Here, we present a fully automated, same-section spatial multiomics workflow that combines the RNAscope™ HiPlexPro RNA in situ hybridization assay with sequential immunofluorescence (seqIF™) on the COMET™ platform. The approach enables co-detection of up to 12-plex RNA and 24-plex protein targets on a single tissue section, allowing highly multiplexed, quantitative interrogation of cellular states and cell-cell interactions while avoiding the sample consumption and registration challenges of serial-section methods.
Applied across formalin-fixed paraffin-embedded human solid tumors, the workflow resolved the spatial architecture of the immune compartment with high sensitivity and reproducibility. RNAscope™ probes for cytokines, chemokines, and immune-relevant transcripts, many of which lack reliable antibodies, were paired with high-plex protein markers to map T-cell, macrophage, and stromal populations across tumor core and invasive margin. This integrated readout links transcriptional programs to key cell types within the tumor-immune landscape.
By uniting gold-standard RNAscope™ RNA detection with high-plex COMET™ protein profiling on the same section, Bio-Techne Spatial provides a scalable, quantitative platform for decoding the tumor immune microenvironment. The workflow opens new avenues for biomarker discovery, mechanistic immuno-oncology studies, and translational research aimed at patient stratification and the development of next-generation immunotherapies.
Speaker
Joanna Kowal, Ph.D.
Senior Scientific Affairs Manager
Bio-Techne Spatial
Joanna completed her Master's degree in biotechnology from Jagiellonian University in Krakow, Poland. Afterwards she joined Institut Curie, Paris, France, where she developed a proteomic cartography of extracellular vesicles in the frame of her Ph.D. research project. She obtained a Ph.D. degree from Université Paris Descartes in 2016. During her postdoctoral training at the University of Lausanne, Joanna interrogated the interactions within the tumor microenvironment with a focus on crosstalk between immune and malignant cells in the context of primary brain tumors. She joined Lunaphore in 2020 and since then works on bringing spatial biology to every laboratory.
September 2
Panel Discussion
Wednesday, September 2
12:30 - 13:15
Main Hall
As spatial biology continues to transform our understanding of disease, successful adoption depends on effective collaboration across the scientific community. This panel brings together leaders from academia, industry, clinical research, and publishing to discuss the shared responsibilities and opportunities that will shape the future of the field.
Speaker
Joanna Kowal, Ph.D.
Senior Scientific Affairs Manager
Bio-Techne Spatial
Joanna completed her Master's degree in biotechnology from Jagiellonian University in Krakow, Poland. Afterwards she joined Institut Curie, Paris, France, where she developed a proteomic cartography of extracellular vesicles in the frame of her Ph.D. research project. She obtained a Ph.D. degree from Université Paris Descartes in 2016. During her postdoctoral training at the University of Lausanne, Joanna interrogated the interactions within the tumor microenvironment with a focus on crosstalk between immune and malignant cells in the context of primary brain tumors. She joined Lunaphore in 2020 and since then works on bringing spatial biology to every laboratory.
September 1
Presentation
Tuesday, September 1
5:30–5:40 PM
Main Hall
Resolving the spatial organization of the tumor microenvironment is central to understanding immune evasion, predicting response to immunotherapy, and stratifying patients. Meeting these goals requires technologies that can co-detect transcripts and proteins in intact tissue, at single-cell resolution, without exhausting limited clinical samples. Bio-Techne Spatial delivers an integrated solution built for this challenge.
Here, we present a fully automated, same-section spatial multiomics workflow that combines the RNAscope™ HiPlexPro RNA in situ hybridization assay with sequential immunofluorescence (seqIF™) on the COMET™ platform. The approach enables co-detection of up to 12-plex RNA and 24-plex protein targets on a single tissue section, allowing highly multiplexed, quantitative interrogation of cellular states and cell-cell interactions while avoiding the sample consumption and registration challenges of serial-section methods.
Applied across formalin-fixed paraffin-embedded human solid tumors, the workflow resolved the spatial architecture of the immune compartment with high sensitivity and reproducibility. RNAscope™ probes for cytokines, chemokines, and immune-relevant transcripts, many of which lack reliable antibodies, were paired with high-plex protein markers to map T-cell, macrophage, and stromal populations across tumor core and invasive margin. This integrated readout links transcriptional programs to key cell types within the tumor-immune landscape.
By uniting gold-standard RNAscope™ RNA detection with high-plex COMET™ protein profiling on the same section, Bio-Techne Spatial provides a scalable, quantitative platform for decoding the tumor immune microenvironment. The workflow opens new avenues for biomarker discovery, mechanistic immuno-oncology studies, and translational research aimed at patient stratification and the development of next-generation immunotherapies.
Speaker
Joanna Kowal, Ph.D.
Senior Scientific Affairs Manager
Bio-Techne Spatial
September 2
Panel Discussion
Wednesday, September 2
12:30 - 13:15
Main Hall
As spatial biology continues to transform our understanding of disease, successful adoption depends on effective collaboration across the scientific community. This panel brings together leaders from academia, industry, clinical research, and publishing to discuss the shared responsibilities and opportunities that will shape the future of the field.
Speaker
Joanna Kowal, Ph.D.
Senior Scientific Affairs Manager
Bio-Techne Spatial