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Spatial Biology beyond immuno-oncology - Flexibility to scale up discoveries

The Spatial Biology Week™️

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Spatial Biology beyond immuno-oncology - Flexibility to scale up discoveries

  • The added value of in situ spatial proteomics
  • The next era of pathology – from single plex to broad panels
  • How can you access the latest spatial omics technologies for your research

Speaker

Charlotte Stadler, PhD

Charlotte Stadler, PhD

Co-Director Spatial and Single Cell Biology Platform, Head of Spatial Proteomics

SciLifeLab

Charlotte Stadler is a co-director of the Spatial and single cell Biology (SSCB) platform at Science for Life Laboratory. She is also the Head of the National Spatial Proteomics facility. She received her Ph.D. in 2012 within the framework of the Human Protein Atlas (HPA) project, with Prof. Emma Lundberg and Prof. Mathias Uhlén as her supervisors. During her PhD she established many of the protocols and pipelines for image based subcellular protein profiling that are used in the Human Protein Cell Atlas.

Today, her main focus is to develop and implement services and technologies that can be offered by the Spatial Proteomics Facility. Her internal research projects focus on the implementation of multiplexed imaging solutions into clinical practice but also on integrating different omics types for a more complete molecular understanding of the tissue sample biology.

For more information:

https://www.scilifelab.se/facilities/cell-profiling/

https://www.proteinatlas.org/

The SARS-CoV-2 virus is not only associated with respiratory tract infection, but can also infect other organs such as the placenta, resulting in unique clinical syndromes depending on the organ infected. Through the use of multiomic spatial profiling of SARS-CoV-2 infected tissue, including lung and placenta, we demonstrate that:

  • Detection of virus in tissue requires a robust muitiomic approach
  • SARS-CoV-2 infection elicits a unique inflammatory response
  • Virus infection in lung is associated with dysregulated collagen synthesis
  • Placental infection is typified by competing anti-viral and immune evasive responses.

Speaker

Matthew Pugh, MD PhD

Matthew Pugh, MD PhD

MRC Clinical Research Training Fellow

University of Birmingham

  • Pros and Cons of an open technology platform for spatial biology
  • Spatial protein versus RNA biomarkers
  • Most promising fields outside oncology where spatial biology can make a long-lasting impact

Speakers

Jared K Burks, PhD

Jared K Burks, PhD

Professor & Co-Director of the Flow Cytometry & Cellular Imaging Core Facility

The University of Texas MD Anderson Cancer Center

I started my carrier at Texas A&M University learning about patterns in genes and proteins, allowing and facilitating subcellular protein trafficking.  As I have progressed to MD Anderson Cancer Center, I have scaled to cellular trafficking attempting to understand the spatial distribution of cells in organ systems during disease.  As in many parts of life, form equals functions.  How our cells organize speaks to how they function and respond to their local environment.  Bringing together multi-omics approaches allows for greater clarity in these imaging snapshots that are collected.

Charlotte Stadler, PhD

Charlotte Stadler, PhD

Co-Director Spatial and Single Cell Biology Platform, Head of Spatial Proteomics

SciLifeLab

Charlotte Stadler is a co-director of the Spatial and single cell Biology (SSCB) platform at Science for Life Laboratory. She is also the Head of the National Spatial Proteomics facility. She received her Ph.D. in 2012 within the framework of the Human Protein Atlas (HPA) project, with Prof. Emma Lundberg and Prof. Mathias Uhlén as her supervisors. During her PhD she established many of the protocols and pipelines for image based subcellular protein profiling that are used in the Human Protein Cell Atlas.

Today, her main focus is to develop and implement services and technologies that can be offered by the Spatial Proteomics Facility. Her internal research projects focus on the implementation of multiplexed imaging solutions into clinical practice but also on integrating different omics types for a more complete molecular understanding of the tissue sample biology.

For more information:

https://www.scilifelab.se/facilities/cell-profiling/

https://www.proteinatlas.org/

Matthew Pugh, MD PhD

Matthew Pugh, MD PhD

MRC Clinical Research Training Fellow

University of Birmingham

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