COMET™
![COMET™'s product front view](https://lunaphore.com/wp-content/uploads/2023/03/COMET_Front_closed_shadow-e1680256872361.png)
Scalable hyperplexing
![](https://lunaphore.com/wp-content/uploads/2023/10/Lunaphore_icon_hyperprex-throughput.png)
Unmatched hyperplex throughput with walk-away automation
- Perform a 20-plex on cohorts of 20 samples in just 1 week.
- Virtually unlimited plex level capability (perform multiple additional runs on the same slide).
- Slide in, OME-TIFF image out (with background already subtracted).
![](https://lunaphore.com/wp-content/uploads/2021/07/Lunaphore_icon_preferred-antibody.png)
Rapid and flexible panel development using label-free antibodies
- Use standard, off-the-shelf, label-free primary antibodies. No conjugation or barcoding needed.
- Transfer your existing know-how of IHC / IF antibodies to your COMET™ library.
- Generate hyperplex protocols automatically in just a few clicks.
![](https://lunaphore.com/wp-content/uploads/2021/07/Lunaphore_icon_High-quality.png)
True reproducibility and tissue preservation
- Maximize reproducibility thanks to a fully automated workflow and precision microfluidics.
- Tissue morphology and epitope stability are fully preserved for downstream applications.
- Avoid undesired variability thanks to no upstream antibody conjugations.
Hyperplex workflow without user intervention
A fully integrated system across staining, image acquisition and image pre-processing.
Build custom panels with full flexibility in just a few clicks
COMET™ is:
The first universal, end-to-end, spatial biology solution
A tool to answer your research needs from early discovery to late-stage translational and clinical research. Discover new biological pathways and identify biomarker “signatures” with clinical relevance to support your development of new diagnostic tools and therapies.
A companion in your spatial biology journey
Kick-start your spatial biology adoption with an intuitive and automated platform, and a comprehensive, one-stop-shop, product suite. Be up and running in days.
Your research and development partner
Identify the location and assess abundance of a high number of proteins on a single tissue section, while obtaining large amounts of contextual information. Deep-dive into complex cell interactions in a wide range of applications in immuno-oncology, immunology, neuroscience and infectious diseases.
![DAPI](https://lunaphore.com/wp-content/uploads/2021/07/DAPI.jpg)
![aSMA](https://lunaphore.com/wp-content/uploads/2021/07/aSMA.jpg)
![CD3](https://lunaphore.com/wp-content/uploads/2021/07/CD3.jpg)
![CD4](https://lunaphore.com/wp-content/uploads/2021/07/CD4.jpg)
![CD8](https://lunaphore.com/wp-content/uploads/2021/07/CD8.jpg)
![CD11b](https://lunaphore.com/wp-content/uploads/2021/07/CD11b.jpg)
![CD11c](https://lunaphore.com/wp-content/uploads/2021/07/CD11c.jpg)
![CD15](https://lunaphore.com/wp-content/uploads/2021/07/CD15.jpg)
![CD20](https://lunaphore.com/wp-content/uploads/2021/07/CD20.jpg)
![CD25](https://lunaphore.com/wp-content/uploads/2021/07/CD25.jpg)
![CD38](https://lunaphore.com/wp-content/uploads/2021/07/CD38.jpg)
![CD45](https://lunaphore.com/wp-content/uploads/2021/07/CD45.jpg)
![CD45RA](https://lunaphore.com/wp-content/uploads/2021/07/CD45RA.jpg)
![CD56](https://lunaphore.com/wp-content/uploads/2021/07/CD56.jpg)
![CD68](https://lunaphore.com/wp-content/uploads/2021/07/CD68.jpg)
![CD163](https://lunaphore.com/wp-content/uploads/2021/07/CD163.jpg)
![FOXP3](https://lunaphore.com/wp-content/uploads/2021/07/FOXP3.jpg)
![HLA-DR](https://lunaphore.com/wp-content/uploads/2021/07/HLA-DR.jpg)
![Ki-67](https://lunaphore.com/wp-content/uploads/2021/07/Ki67.jpg)
![LAG3](https://lunaphore.com/wp-content/uploads/2021/07/LAG3.jpg)
![Na/K-ATPase](https://lunaphore.com/wp-content/uploads/2021/07/NaK-ATPase.jpg)
![CK](https://lunaphore.com/wp-content/uploads/2021/07/panCK.jpg)
![PD-1](https://lunaphore.com/wp-content/uploads/2021/07/PD-1.jpg)
![PD-L1](https://lunaphore.com/wp-content/uploads/2021/07/PD-L1.jpg)
![Vimentin](https://lunaphore.com/wp-content/uploads/2021/07/Vimentin.jpg)
Tap to toggle on and off.
24 markers on tonsil tissue.
Total protocol time: 5h. Fully automated on COMET™.
End-to-end: sample in, data out
Click on the buttons to read the description.
![Product front view](https://lunaphore.com/wp-content/uploads/2023/03/COMET-system.png)
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Reagents Module
Reagents and buffers are loaded in small and large volume reservoirs respectively and delivered to the sample through microfluidic channels.
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Staining Module
Rotary stage where up to four slides are inserted and clamped against the COMET™ Chip. Its unique design allows for staining and imaging parallelization.
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Image Viewer
Following image acquisition, the Viewer can open the resulting image files. The software facilitates visualization and exports the data for image analysis.
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Fully automated multiomics on COMET™
Perform true spatial multiomics assays, simultaneously detecting any RNA and protein targets on the same tissue section using RNAscope™ HiPlex Pro and off-the-shelf, non-conjugated primary antibodies, with subcellular resolution.
A fully automated workflow from target probe hybridization to multiomic imaging, requiring no user intervention, facilitates a deeper understanding of cellular processes and disease mechanisms.
Kick-start your assay development
Run your custom hyperplex panels in days. Kick-start your assay development using the SPYRE™ Antibody Panels:
- T Cell Core Panel
- TIL Core Panel
- Immune Core Panel
- Immuno-Oncology Core Panel
Use the Panel Builder to build ready-to-use protocols in a few clicks, and customize your assays.
Analyze your images
Choose your preferred Image Analysis platform for your image.
COMET™ is fully integrated with HORIZON™ by Lunaphore: an entry intuitive tool to start your hyperplex image analysis journey with no coding experience.
COMET™ has proven compatibility with Oncotopix® Discovery (Visiopharm), HALO® & HALO AI™ (Indica Labs), ATOM (Nucleai) and QuPath.
Access Lab
Interested in acquiring a COMET™ solution for your lab?
Simplify your decision making process and technology adoption using your own samples and reagents.