Spatial immunofluorescence is a game-changer technique in the field of immuno-oncology, neuroscience, and infectious diseases. When developing multiplex immunofluorescence panels, tissue preservation and efficient antibody removal are key factors to ensure signal specificity. COMET™ is based on microfluidic technology and performs sequential immunofluorescence (seqIF™) with repetitive cycles of staining, imaging, and elution. COMET™ performs fast and finely controlled antibody staining incubations without harsh tissue photobleaching or tissue ablation.